Monoamine oxidase inactivation: From pathophysiology to therapeutics☆

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Inhibition of monoamine oxidase by stilbenes from Rheum palmatum

Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...

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Inhibition of monoamine oxidase by stilbenes from Rheum palmatum

Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...

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Suicide inactivation of monoamine oxidase by trans-phenylcyclopropylamine.

The mechanism of the inactivation of monoamine oxidase by arylcyclopropylamines has been studied using [%‘4C]DL-tmns-phenylcyclopropylamine. This compound is a typical suicide inhibitor of bovine liver monoamine oxidase. It reacts rapidly and irreversibly with the enzyme, resulting in the incorporation of slightly over 1 mol of the inhibitor; the reaction is prevented but not reversed by substr...

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Mitochondrial monoamine oxidase. Inactivation by pargyline. Adduct formation.

Pargyline (N-benzylN-methyl-Z-propynylamine), known to react stoichiometrically and irreversibly with the mitochondrial monoamine oxidase of bovine kidney, involving simultaneously the enzyme’s flavin component, (HELLERMAN, L., AND ERWIN, V. G. (1968) J. Biol. Chem. 243, 5234-5243), has been shown to inactivate by forming a stable adduct with the flavin residue. Thus, the reaction of pargyline ...

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Monoamine oxidase inhibition.

Introduction The discovery that inhibitors of monoamine oxidase (EC 1.4.3.4.; MAO) are antidepressants (see [ l ] for a review) has resulted in the synthesis of large numbers of inhibitors, several of which have proved to be valuable in clinical use. Such work was given added impetus when it was recognized that there are two monoamine oxidases in most mammalian tissues, MAO-A and MAO-B, with di...

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ژورنال

عنوان ژورنال: Advanced Drug Delivery Reviews

سال: 2008

ISSN: 0169-409X

DOI: 10.1016/j.addr.2008.06.002